Misitura Lawal-Arowona, Nigerian scholar, who is pursuing her research at MSU under fellowship sanctioned by the Italy-headquartered Third World Academy of Sciences and Department of Biotechnology, Government of India, has developed metal attached anti-TB drug.
This has improved the efficiency of the anti-TB drugs compared to normal drugs that are consumed globally.
The PhD scholar with the University of Ilorin, who made this known in a statement released to Nigeria however, promised to tackle the menace of tuberculosis (TB), both in African countries as well as India.
Nigeria, according to her is among the 14 high burden countries for TB, TB/HIV and multi-drug resistant TB.
She says “The country is ranked seventh among the 30 high TB burden countries and second in Africa. The problem of TB in Nigeria has been made worse by the issues of drug resistant TB and the HIV/AIDS epidemic. It is estimated that 4, 07,000 people in Nigeria have TB in a year.
“Earlier studies have proved that when a metal is attached with a pharmaceutical, it increases efficacy of the drug,”
Adding that, taking a cue from cisplatin, an anti-cancer drug, whose efficacy improved after applying platinum as metal, the scholar worked on multiple metal-based drugs to see whether efficiency of anti-TB drugs can be increased by attaching metals to it.
According to her, she used metals like ion, cobalt, copper and zinc to prepare the metallodrugs. The drugs, which have been developed, include ciprofloxacin HCl, ofloxacin, pyrazinamide and moxifloxacin HCl. Presently, there is no metal-based anti-TB drug available in the market.
Meanwhile, Rajendrasinh Jadeja from MSU’s chemistry department, who is mentoring the Nigerian scholar, says “When we compared the metallodrugs with the original anti-TB drugs, the metallodrugs were more effective.
“We did in vitro test against bacteria. The metals we have chosen are non-harmful to human beings. Also, we found that of all the metallodrugs, the copper complex of ciprofloxacin is most effective.”
SIKIRAT SHEHU, Ilorin
